反应详情

Palladium hydroxide on carbon (1 g, 20 wt % Pd) was added to a solution of Example 93A (2.66 g, 9.66 mmol) in methanol (40 mL) and ethyl acetate (10 mL). The mixture was placed under vacuum and filled with hydrogen (balloon) and allowed to stir for 3 hours before it was filtered through a pad of Celite using methanol to rinse. The solvent was evaporated and the product was dissolved in dichloromethane and dried over Na2SO4. After filtration and concentration, the title compound was isolated as a slightly yellow solid and used in the following step without further purification.

1. filtrationwas filtered through a pad of Celite
2. washto rinse
3. customThe solvent was evaporated
4. dissolutionthe product was dissolved in dichloromethane
5. dry with materialdried over Na2SO4
6. filtrationAfter filtration and concentration