HCID 178496196, compound → HCID 178496195, compound

HRID 2042822Notes

Reaction equation

HRID 2042822 reaction equation
[NH2:1][C:2]1[C:20]([N+:21]([O-])=O)=[CH:19][C:5]([C:6]([NH:8][C@H:9]2[CH2:14][CH2:13][C@H:12]([C:15]([F:18])([F:17])[F:16])[CH2:11][CH2:10]2)=[O:7])=[C:4]([O:24][CH2:25][CH2:26][O:27][CH3:28])[N:3]=1>[Ni].C1COCC1>[NH2:21][C:20]1[C:2]([NH2:1])=[N:3][C:4]([O:24][CH2:25][CH2:26][O:27][CH3:28])=[C:5]([CH:19]=1)[C:6]([NH:8][C@H:9]1[CH2:10][CH2:11][C@H:12]([C:15]([F:16])([F:17])[F:18])[CH2:13][CH2:14]1)=[O:7]

Participants

4

Reactant 1

HCID 178496196HCID 178496196, compound

Product 1

HCID 178496195HCID 178496195, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

6-Amino-2-(2-methoxy-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (140 mg, 0.34 mmol), THF (20 mL) and Ra—Ni (40 mg) is stirred for 2 h at rt under a hydrogen atmosphere (3.0 bar). The catalyst is removed by filtration and the mixture is concentrated to give the sub-title compound.

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe mixture is concentrated

Sources & evidence

ORD record
ord-3478b67660f742e696c96262ef629b9e
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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