Diisopropylcarbodiimide → HCID 178447328, compound

HRID 2042847Notes

Reaction equation

HRID 2042847 reaction equation
[F:1][C:2]1[C:15]([N:16]=[C:17]=S)=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8].[NH2:20][C:21]1[C:22]([NH2:45])=[N:23][C:24]([O:40][CH2:41][CH:42]([F:44])[F:43])=[C:25]([CH:39]=1)[C:26]([NH:28][C@H:29]1[CH2:34][CH2:33][C@H:32]([C:35]([F:38])([F:37])[F:36])[CH2:31][CH2:30]1)=[O:27].CC(C)N=C=NC(C)C>>[F:1][C:2]1[C:15]([NH:16][C:17]2[NH:20][C:21]3[C:22]([N:45]=2)=[N:23][C:24]([O:40][CH2:41][CH:42]([F:44])[F:43])=[C:25]([C:26](=[O:27])[NH:28][C@H:29]2[CH2:30][CH2:31][C@H:32]([C:35]([F:37])([F:36])[F:38])[CH2:33][CH2:34]2)[CH:39]=3)=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8]

Participants

4

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840194N-(2-fluoro-4-chloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamideHCID 178507778HCID 178507778, compound

Product 1

HCID 178447328HCID 178447328, compound

Procedure

The title compound is prepared from N-(2-fluoro-4-chloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (55 mg, 0.18 mmol) and 5,6 diamino-2-(2,2-difluoro-ethoxy)-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (70 mg, 0.18 mmol) with DIC in analogy to examples 8a/8b.

Sources & evidence

ORD record
ord-232aa0d989f7445bae9c7d500bbf7414
Source dataset
uspto-grants-2013_11
Patent number
US08586604B2

Reaction notes

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