Hydrochloric Acid → 3-[7-[[4-[[methyl(2-morpholin-4-ylethyl)amino]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

HRID 204337Notes

Reaction equation

HRID 204337 reaction equation
[CH2:55]1[O:56][CH2:57][CH2:58][CH2:59]1.[CH3:40][C:41]([CH3:42])([O-:43])[CH3:44].[Cl:52][CH2:53][Cl:54].[ClH:46].[K+:45].[NH2:1][C:2]([CH:3]([CH2:4][CH2:5][C:6]([O:8][CH3:7])=[O:9])[N:10]1[C:11](=[O:38])[c:12]2[cH:13][cH:14][cH:15][c:16]([O:19][CH2:20][c:21]3[cH:22][cH:23][c:24]([CH2:27][N:28]([CH2:29][CH2:30][N:31]4[CH2:32][CH2:33][O:34][CH2:35][CH2:36]4)[CH3:37])[cH:25][cH:26]3)[c:17]2[CH2:18]1)=[O:39].[Na+:51].[O-:47][C:48]([OH:49])=[O:50]>>[NH:1]1[C:2](=[O:39])[CH:3]([N:10]2[C:11](=[O:38])[c:12]3[cH:13][cH:14][cH:15][c:16]([O:19][CH2:20][c:21]4[cH:22][cH:23][c:24]([CH2:27][N:28]([CH2:29][CH2:30][N:31]5[CH2:32][CH2:33][O:34][CH2:35][CH2:36]5)[CH3:37])[cH:25][cH:26]4)[c:17]3[CH2:18]2)[CH2:4][CH2:5][C:6]1=[O:8]

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 813Potassium CationHCID 923Sodium ionHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 45749132-Methylpropan-2-olateHCID 67335211methyl 5-amino-4-[7-[[4-[[methyl(2-morpholin-4-ylethyl)amino]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]-5-oxopentanoate

Product 1

HCID 583892743-[7-[[4-[[methyl(2-morpholin-4-ylethyl)amino]methyl]phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione

Sources & evidence

ORD record
ord-50dc1897077b45a9aba577e4e5d34bea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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