反应详情

Add propyl iodide (5.74 g, 33.77 mmol) to 3-bromo-5-fluoro-phenol (4.30 g, 22.51 mmol) and cesium carbonate (11.00 g, 33.77 mmol) in N,N-dimethylformamide (75 mL) and stir at room temperature 1 hour, then heat at 50° C. for 1 hour. Cool to room temperature and dilute with hexanes. Wash (water, 1N lithium chloride, saturated aqueous sodium chloride), dry (magnesium sulfate), filter and concentrate to give the desired compound as a colorless oil, 4.40 g (83.8%).

1. temperatureheat at 50° C. for 1 hour
2. temperatureCool to room temperature
3. washWash (water, 1N lithium chloride, saturated aqueous sodium chloride)
4. dry with materialdry (magnesium sulfate)
5. filtrationfilter
6. concentrationconcentrate