Ammonia → HCID 16067939, compound

HRID 2043843Notes

Reaction equation

HRID 2043843 reaction equation
Cl.[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH2:12])[CH2:3]1)[CH2:9]2.[Cl:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][CH:15]=1.N>>[N:2]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:4]([C@H:5]3[NH:12][C:18](=[O:19])[C:17]3[CH:21]=[CH:22][C:14]([Cl:13])=[CH:15][CH:16]=3)[CH2:3]1)[CH2:9]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 63184-Chlorobenzoic AcidHCID 671521221-Azatricyclo[3.3.1.1,3,7]decan-4-amine hydrochloride

Product 1

HCID 16067939HCID 16067939, compound

Procedure

Prepared from (4r)-1-azatricyclo[3.3.1.13,7]dec-4-ylamine hydrochloride and 4-chlorobenzoic acid (Aldrich) according to method A; yield 29 mg, 0.07 mmol (33%): 1H NMR (300 MHz, methanol-d4) δ 2.06-2.30 (m, 5H), 2.45 (s, 2H), 3.48 (d, J=12 Hz, 2 H), 3.55 (s, 2H), 3.80 (d, J=12 Hz, 2H), 4.25 (s, 1H), 7.49 (d, J=9 Hz, 2H), 7.86 (d, J=9 Hz, 2H); MS (DCI/NH3) m/z 291 (M+H)+; Anal. C16H19Cl2N2O.HCl.0.45HCl: C, H, N.

Sources & evidence

ORD record
ord-914122871a7d45a3ae46b88bab0c3b5d
Source dataset
uspto-grants-2013_11
Patent number
US08586746B2

Reaction notes

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