Hydrochloric Acid → HCID 16101137, compound

HRID 2043891Notes

Reaction equation

[CH:1]1([N:7]([CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15]CC(O)=O)=[CH:13][N:14]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.C1(CCN)CCCCC=1.C1(=O)CCCCC1.C([O:48][C:49](=[O:52])[CH2:50][CH3:51])C.Cl.CCN(C(C)C)C(C)C>>[C:23]1([CH2:22][CH2:21][N:7]([CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[C:8](=[O:20])[NH:9][C:10]2[S:11][C:12]([S:15][CH2:51][CH2:50][C:49]([OH:52])=[O:48])=[CH:13][N:14]=2)[CH2:28][CH2:27][CH2:26][CH2:25][CH:24]=1

Participants

Reactant 6

HCID 313Hydrochloric Acid

HCID 7749Ethyl Propionate

HCID 7967Cyclohexanone

HCID 81531Diisopropylethylamine

HCID 11993791[2-(3-Cyclohexyl-3-phenethylureido)-thiazol-5-ylsulfanyl]-acetic acid

HCID 12510228HCID 12510228, compound

Product 1

HCID 16101137HCID 16101137, compound

Procedure

Prepared as described for the synthesis of [2-(3-cyclohexyl-3-phenethyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid, from 2-(1-cyclohexenyl)ethylamine hydrochloride, cyclohexanone and 2-amino-thiazol-5-ylsulfanyl)-propionic acid ethyl ester. The hydrochloride was added one equivalent DIPEA prior to the reaction.

Workup

customPrepared
customto the reaction

Sources & evidence

ORD record: ord-3255a70d96a94cdfa95150e425faacbb
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08586614B2

Reaction notes

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