Sulfuric Acid → HCID 58320703, compound

HRID 2044029Notes

Reaction equation

HRID 2044029 reaction equation
[Cl:1][C:2]1[C:3]([N:8]2[C:12](C(Cl)(Cl)Cl)=[CH:11][C:10]([CH2:17][OH:18])=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1.OS(O)(=O)=O.[C:24]([O-:27])(O)=[O:25].[Na+]>>[Cl:1][C:2]1[C:3]([N:8]2[C:12]([C:24]([OH:27])=[O:25])=[CH:11][C:10]([CH2:17][OH:18])=[N:9]2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 58320695HCID 58320695, compound

Product 1

HCID 58320703HCID 58320703, compoundYield 90%

Conditions

Temperature
0 °C

Procedure

38.7 g (0.1 mol) of [1-(3-chloropyridin-2-yl)-5-(trichloromethyl)-1H-pyrazol-3-yl]methanol and 10 g of H2SO4 (as 10% solution in water) were stirred for 3 hours at 80° C. The mixture was cooled to 0° C., made neutral with NaHCO3 solution and the precipitate was filtered off, washed with acetonitrile and dried. Yield 90%. M.p. 178-180° C.

Workup

  1. filtrationthe precipitate was filtered off
  2. washwashed with acetonitrile
  3. customdried

Sources & evidence

ORD record
ord-321a1bf302bc4b64b485da82de2381ca
Source dataset
uspto-grants-2013_11
Patent number
US08586753B2

Reaction notes

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