4-Chloro-3-nitrobenzenesulfonamide → HCID 67126605, compound

HRID 2045017Notes

Reaction equation

HRID 2045017 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].Cl.Cl.[NH2:17][CH2:18][C:19]1([NH2:25])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.C(N(CC)CC)C>O1CCOCC1.O>[NH2:25][C:19]1([CH2:18][NH:17][C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][C:3]=2[N+:12]([O-:14])=[O:13])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

6

Reactant 3

HCID 73244-Chloro-3-nitrobenzenesulfonamideHCID 8471TriethylamineHCID 67227314HCID 67227314, compound

Product 1

HCID 67126605HCID 67126605, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 4-chloro-3-nitrobenzenesulfonamide, 4-(aminomethyl)tetrahydro-2H-pyran-4-amine bis-hydrochloric acid salt and triethylamine in dioxane (10 mL) was heated at 110° C. overnight. After cooling, the reaction mixture was diluted with water (10 mL), and the solid was filtered to give the title compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered

Sources & evidence

ORD record
ord-ff449a6d15fe4c309b809f5b14c0efc3
Source dataset
uspto-grants-2013_11
Patent number
US08586754B2

Reaction notes

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