反应详情

温度

70 °C

A mixture of EXAMPLE 157B (300 mg), (3-bromopropoxy)(tert-butyl)dimethylsilane (304 mg) and cesium carbonate (967 mg) was suspended in anhydrous N,N-dimethylformamide (5 mL). The reaction mixture was heated at 70° C. overnight. The reaction mixture was cooled to room temperature and diluted with ethyl acetate. The organic phase was washed with water, brine, dried over anhydrous sodium sulfate, and concentrated. The crude material was purified using flash column purification with 3-10% methanol/dichloromethane to afford the title compound.

1. temperatureThe reaction mixture was cooled to room temperature
2. washThe organic phase was washed with water, brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated
5. customThe crude material was purified
6. customflash column purification with 3-10% methanol/dichloromethane