Acetone → Di-Tert-Butyl Iodomethyl Phosphate

HRID 2045887Notes

Reaction equation

HRID 2045887 reaction equation
[P:1]([O:13][CH2:14]Cl)([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[I-:16].[Na+].CC(C)=O>C(#N)C>[P:1]([O:13][CH2:14][I:16])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

5

Reactant 3

HCID 180AcetoneHCID 5238Sodium IodideHCID 11701630Di-tert-butyl (chloromethyl) phosphate2×

Product 1

HCID 58196853Di-Tert-Butyl Iodomethyl Phosphate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared by halogen exchange reaction of di-tert-butyl chloromethyl phosphate (Intermediate 1) with sodium iodide in suitable solvent such as dry acetone or acetonitrile.

Sources & evidence

ORD record
ord-5d0d065177be489e8018d0a8042b788f
Source dataset
uspto-grants-2013_11
Patent number
US08592398B2

Reaction notes

Loading…