Water → 1-{5-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophen-2-yl}-ethylamine

HRID 2045953Notes

Reaction equation

HRID 2045953 reaction equation
O.[N:2]([CH:5]([C:7]1[S:11][C:10]([C:12]2[CH2:16][C:15]([C:21]3[CH:26]=[C:25]([Cl:27])[CH:24]=[C:23]([Cl:28])[CH:22]=3)([C:17]([F:20])([F:19])[F:18])[O:14][N:13]=2)=[CH:9][C:8]=1[CH3:29])[CH3:6])=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1>[Cl:28][C:23]1[CH:22]=[C:21]([C:15]2([C:17]([F:18])([F:20])[F:19])[O:14][N:13]=[C:12]([C:10]3[S:11][C:7]([CH:5]([NH2:2])[CH3:6])=[C:8]([CH3:29])[CH:9]=3)[CH2:16]2)[CH:26]=[C:25]([Cl:27])[CH:24]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 866812913-[5-(1-Azido-ethyl)-4-methyl-thiophen-2-yl]-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole

Product 1

HCID 665872941-{5-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophen-2-yl}-ethylamineYield 37.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Water (2 ml) is added to a mixture of 3-[5-(1-azido-ethyl)-4-methyl-thiophen-2-yl]-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazole (0.80 g) and triphenylphosphine (0.93 g) in tetrahydrofuran (9 ml). After 18 hours at 50° C., the reaction mixture is concentrated in vacuo. The crude product is purified on a semi-preparative HPLC to yield 1-{5-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophen-2-yl}-ethylamine (0.284 g) as an orange solid.

Workup

  1. concentrationthe reaction mixture is concentrated in vacuo
  2. customThe crude product is purified on a semi-preparative HPLC

Sources & evidence

ORD record
ord-8b9e6180f5af43ddbd16d33795795f67
Source dataset
uspto-grants-2013_11
Patent number
US08592418B2

Reaction notes

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