反应详情

To a stirred suspension of 150 mg of 2-chloro-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide (XV) (0.52 mmol) in N,N-dimethylformamide (1.4 mL), 9 mL of a 33% solution of methylamine in ethanol were added (mM). The reaction mixture was stirred at room temperature for 3 hours. The ethanol was then evaporated under reduced pressure and the mixture was diluted with diethyl ether and filtered. A light-yellow solid was then collected, washed with ether then with cold water and dried. The title compound was obtained in moderate yield (100 mg, 68%).

1. additionwere added (mM)
2. customThe ethanol was then evaporated under reduced pressure
3. additionthe mixture was diluted with diethyl ether
4. filtrationfiltered
5. customA light-yellow solid was then collected
6. washwashed with ether
7. dry with materialwith cold water and dried