Tetrahydrofuran → HCID 178468657, compound

HRID 204599Notes

Reaction equation

HRID 204599 reaction equation
[Br:24][c:25]1[cH:26][n:27][c:28]([NH:34][c:35]2[cH:36][cH:37][c:38]([N:41]3[CH:42]4[CH2:43][N:44]([CH:48]([CH3:49])[CH3:50])[CH:45]([CH2:46]3)[CH2:47]4)[cH:39][cH:40]2)[c:29]2[n:30]1[n:31][cH:32][n:33]2.[CH2:1]([Sn:2]([CH2:3][CH2:4][CH2:5][CH3:16])([c:6]1[cH:7][c:8]([C:11](=[O:12])[O:13][CH2:14][CH3:15])[n:9][nH:10]1)[CH2:17][CH2:18][CH2:19][CH3:20])[CH2:21][CH2:22][CH3:23].[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[Pd:56]([Cl:57])[Cl:58].[c:59]1([P:60]([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[cH:73][cH:74][cH:75][cH:76][cH:77]1.[c:78]1([P:79]([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)[cH:92][cH:93][cH:94][cH:95][cH:96]1>>[c:6]1(-[c:25]2[cH:26][n:27][c:28]([NH:34][c:35]3[cH:36][cH:37][c:38]([N:41]4[CH:42]5[CH2:43][N:44]([CH:48]([CH3:49])[CH3:50])[CH:45]([CH2:46]4)[CH2:47]5)[cH:39][cH:40]3)[c:29]3[n:30]2[n:31][cH:32][n:33]3)[cH:7][c:8]([C:11](=[O:12])[O:13][CH2:14][CH3:15])[n:9][nH:10]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 149720685-Tributylstannyl-1H-pyrazole-3-carboxylic acid ethyl esterHCID 750386355-bromo-N-[4-(5-propan-2-yl-2,5-diazabicyclo[2.2.1]heptan-2-yl)phenyl]-[1,2,4]triazolo[1,5-a]pyrazin-8-amine

Product 1

HCID 178468657HCID 178468657, compound

Sources & evidence

ORD record
ord-7834b18a55664a4db6fae26a58e83a54
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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