Trifluoroacetic acid → HCID 86660884, compound

HRID 2046399Notes

Reaction equation

HRID 2046399 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[C@@H:13]([NH2:14])[CH2:12][CH2:11][CH2:10][C:9]1([F:16])[F:15])(C)(C)C.[C:18]([OH:24])([C:20]([F:23])([F:22])[F:21])=[O:19]>ClCCl>[F:21][C:20]([F:23])([F:22])[C:18]([O-:24])=[O:19].[F:21][C:20]([F:23])([F:22])[C:18]([O-:24])=[O:19].[F:15][C:9]1([F:16])[CH2:10][CH2:11][CH2:12][C@H:13]([NH3+:14])[C@H:8]1[NH3+:7]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58046449HCID 58046449, compound

Product 1

HCID 86660884HCID 86660884, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of tert-butyl[(1R,6S)-6-amino-2,2-difluorocyclohexyl]carbamate (5 g, 19.98 mmol) and TFA (6.16 mL, 80 mmol) in dichloromethane (50 mL) was left to stir overnight, and concentrated to afford the title compound as a brown oil. 19F NMR (CDCl3, 564 MHz) −81.07 (s, 6F); −99.7-−100.1 (d, 1F); −111.1-−111.5 (d, 1F).

Workup

  1. waitwas left
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-a501024bbe3f45b3af43f245bd97e343
Source dataset
uspto-grants-2013_11
Patent number
US08592425B2

Reaction notes

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