Morpholine → HCID 76750917, compound

HRID 2046491Notes

Reaction equation

HRID 2046491 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([CH3:12])[C:9]2[C:8](=[N:13][O:14][CH2:15][C:16]([OH:18])=O)[CH2:7][CH:6]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:5][C:4]=2[N:3]=1.S(Cl)(Cl)=O.[NH:35]1[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1.C(N(CC)CC)C>C(Cl)Cl>[N:35]1([C:16](=[O:18])[CH2:15][O:14][N:13]=[C:8]2[CH2:7][CH:6]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[CH2:5][C:4]3[N:3]=[C:2]([NH2:1])[N:11]=[C:10]([CH3:12])[C:9]2=3)[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1

Participants

6

Reactant 4

HCID 8083MorpholineHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 76750935HCID 76750935, compound2×

Product 1

HCID 76750917HCID 76750917, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared from (2-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-ylideneaminooxy)-acetic acid (compound 69) by treating with thionyl chloride followed by amidation using morpholine and triethylamine in DCM.

Sources & evidence

ORD record
ord-e5cba02108e84063979af4184a9bdc86
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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