反应详情

To a solution of 2-bromo-4-chloro-6-fluoro-N-hydroxy-benzamidine (26.5 g, 99.25 mmol) in 2-propanol (200 ml) was added N,N-dimethylacetamide dimethyl acetal (35.2 ml, 238.20 mmol) slowly at 25° C. and the reaction mixture was stirred for 30 minutes. After completion of the reaction all volatiles were evaporated and the resulting crude product was purified by chromatography (silica gel; hexane/EtOAc 97:3) to obtain the title compound (27.5 g, 58%) as white solid. MS: 290 (M+, 1Br).

1. customAfter completion of the reaction all volatiles
2. customwere evaporated
3. customthe resulting crude product was purified by chromatography (silica gel; hexane/EtOAc 97:3)