Diisopropylethylamine → HCID 58173499, compound

HRID 2047156Notes

Reaction equation

HRID 2047156 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8](COCC[Si](C)(C)C)COCC[Si](C)(C)C)[N:5]2[N:25]=[CH:26][C:27]([C:28]3[CH:29]=[N:30][C:31]4[C:36]([CH:37]=3)=[CH:35][CH:34]=[CH:33][CH:32]=4)=[C:4]2[N:3]=1.[CH3:38][O:39][C:40]([CH:42]1[CH2:46][CH2:45][NH:44][CH2:43]1)=[O:41].C(N(C(C)C)C(C)C)C>CN(C=O)C>[NH2:8][C:6]1[N:5]2[N:25]=[CH:26][C:27]([C:28]3[CH:29]=[N:30][C:31]4[C:36]([CH:37]=3)=[CH:35][CH:34]=[CH:33][CH:32]=4)=[C:4]2[N:3]=[C:2]([N:44]2[CH2:45][CH2:46][CH:42]([C:40]([O:39][CH3:38])=[O:41])[CH2:43]2)[CH:7]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 4114360Methyl Pyrrolidine-3-carboxylateHCID 86664780(5-Chloro-3-quinolin-3-yl-pyrazolo[1,5-a]pyrimidin-7-yl)-bis-(2-trimethylsilanyl-ethoxymethyl)-amine

Product 1

HCID 58173499HCID 58173499, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of 5-chloro-3-(quinolin-3-yl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)-pyrazolo-[1,5-a]pyrimidin-7-amine (55 mg, 0.10 mmoL), methylpyrrolidine-3-carboxylate (52 mg, 0.30 mmoL) and EtN(iPr)2 (86 uL, 0.50 mmoL) in DMF (1.0 mL) was heated at 180° C. under microwave condition for 45 min. The mixture was purified by prep-LC to afford the title compound. LC/MS RT=3.30 min. Mass calculated for, M+H 389.17, observed 389.17.

Workup

  1. customThe mixture was purified by prep-LC

Sources & evidence

ORD record
ord-1e1452cb71a54761a4d3d67a20328de6
Source dataset
uspto-grants-2013_11
Patent number
US08591943B2

Reaction notes

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