反应详情

To a solution of (E)-2-chloro-6-fluorobenzaldehyde oxime (2 g) in 10 mL Dimethylformamide (DMF) at room temperature 0.23 g N-Chlorosuccinimide (NCS) were added. Dry hydrogen chloride was bubbled into the DMF solution until the reaction temperature rise up to 35° C. Then 1.21 g N-chloro-succinimide were added in portions, the temperature was kept at 35-45° C. The reaction mixture was cooled to room temperature and poured into 30 mL ice and extracted with ether. Combined extracts were dried and evaporated to give 2.5 g of 2-chloro-6-fluoro-N-hydroxybenzimidoyl chloride as a yellow oil.

1. customDry hydrogen chloride was bubbled into the DMF solution until the reaction temperature rise up to 35° C
2. additionThen 1.21 g N-chloro-succinimide were added in portions
3. customwas kept at 35-45° C
4. additionpoured into 30 mL ice
5. extractionextracted with ether
6. customCombined extracts were dried
7. customevaporated