Hydrochloric Acid → 2-(3-piperazin-1-yl-phenyl)-1H-benzoimidazole dihydrochloride

HRID 2047370Notes

Reaction equation

HRID 2047370 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[NH:24][C:23]4[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=4[N:21]=3)[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:29]>CO.CCOCC>[ClH:29].[ClH:29].[N:11]1([C:14]2[CH:15]=[C:16]([C:20]3[NH:21][C:22]4[CH:28]=[CH:27][CH:26]=[CH:25][C:23]=4[N:24]=3)[CH:17]=[CH:18][CH:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 595680504-[3-(1H-Benzoimidazol-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 686711782-(3-piperazin-1-yl-phenyl)-1H-benzoimidazole dihydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 4-[3-(1H-benzoimidazol-2-yl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (1.80 g, 4.76 mmol) in MeOH (2 mL), 2M HCl in Et2O (8 mL) was added and the resulting mixture was stirred for 6 h at room temperature.

Sources & evidence

ORD record
ord-25bd64b163eb450a8948b922eb37ad29
Source dataset
uspto-grants-2013_11
Patent number
US08592463B2

Reaction notes

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