反应详情

NaH 60% suspension in mineral oil (0.61 g, 25.5 mmol) was added to a solution of 2-(5-Bromo-2-fluoro-phenyl)-1H-benzoimidazole (3.70 g, 12.76 mmol) in dry THF (100 mL) and the reaction was stirred at room temperature 30 minutes before adding methyl iodide (1.19 mL, 19.1 mmol). Reaction was left stirring for 2 h, then quenched with water (20 mL) The solution was concentrated, then AcOEt (30 mL) was added. The organic solution was separated, washed with brine (10 mL), dried over Na2SO4 and concentrated under reduced pressure to afford 3.80 g of desired compound. (97%).

1. customReaction
2. waitwas left
3. stirringstirring for 2 h
4. customquenched with water (20 mL) The solution
5. concentrationwas concentrated
6. additionAcOEt (30 mL) was added
7. customThe organic solution was separated
8. washwashed with brine (10 mL)
9. dry with materialdried over Na2SO4
10. concentrationconcentrated under reduced pressure