Dichloromethane → HCID 68671994, compound

HRID 2047401Notes

Reaction equation

HRID 2047401 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[N:24]([CH3:25])[C:23]4[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=4[N:21]=3)[CH:15]=2)[CH2:10][CH2:9]1)(C)(C)C.[Cl:31]CCl>CO.Cl.CCOCC>[ClH:31].[CH3:25][N:24]1[C:23]2[CH:26]=[CH:27][CH:28]=[CH:29][C:22]=2[N:21]=[C:20]1[C:16]1[CH:15]=[C:14]([N:11]2[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]2)[CH:19]=[CH:18][CH:17]=1

Participants

6

Reactant 2

HCID 6344DichloromethaneHCID 68671384HCID 68671384, compound

Product 1

HCID 68671994HCID 68671994, compound

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a mixture of {1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidin-4-yl}-carbamic acid tert-butyl ester (2.00 g, 4.93 mmol) in dichloromethane (2 mL) and methanol (1 mL), 2M HCl in Et2O (25 mL) was added and the resulting mixture was stirred overnight at room temperature.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-87f58435edd54ac290c543d26bf66ab0
Source dataset
uspto-grants-2013_11
Patent number
US08592463B2

Reaction notes

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