Potassium Carbonate → HCID 44596058, compound

HRID 2047611Notes

Reaction equation

HRID 2047611 reaction equation
[CH3:1][N:2]1[C:7](SC)=[N:6][C:5]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[N:4][C:3]1=[O:16].Cl.[NH2:18][CH2:19][C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:21].C(=O)([O-])[O-].[K+].[K+]>CC(C)CCO>[CH3:1][N:2]1[C:7]([NH:18][CH2:19][C:20](=[O:21])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[N:6][C:5]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)=[N:4][C:3]1=[O:16]

Participants

5

Reactant 3

HCID 11430Potassium Carbonate2×HCID 2723597Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1)HCID 67182730HCID 67182730, compound

Product 1

HCID 44596058HCID 44596058, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Conditions

Temperature
120 °C

Procedure

To a suspension of 0.12 g (0.51 mmol) of 1-Methyl-6-methylsulfanyl-4-pyridin-4-yl-1H-[1,3,5]triazin-2-one in 1 mL of 3-methyl-1-butanol was added 0.088 g (0.51 mmol) of 2-Amino-1-phenyl-ethanone hydrochloride (commercially available). To the resulting mixture was added 7.1 mg (0.051 mmol) of potassium carbonate. The resulting mixture was stirred at 120° C. for 1 h. Then, 7.1 mg (0.051 mmol) of potassium carbonate were added each hour during 2 h.

Sources & evidence

ORD record
ord-fad381bdde4d491388180807985e5293
Source dataset
uspto-grants-2013_11
Patent number
US08592580B2

Reaction notes

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