反应详情

Ethyl 4-[(5-chloro-6-isobutoxypyridin-3-yl)oxy]-2,5-difluorobenzoate (Preparation 38, 150 mg, 0.389 mmol) and lithium hydroxide (250 mg, 10.44 mmol) were dissolved in water (2.5 mL) and THF (2.5 mL) and stirred at room temperature for 72 hours. The reaction mixture was concentrated in vacuo. The residue was dissolved in EtOAc (10 mL), washed with water (10 mL) and aqueous HCl (2 M, 10 mL), then was dried over sodium sulfate, filtered and concentrated in vacuo to yield the title compound as a white solid (140 mg, 100%):

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionThe residue was dissolved in EtOAc (10 mL)
3. washwashed with water (10 mL) and aqueous HCl (2 M, 10 mL)
4. dry with materialwas dried over sodium sulfate
5. filtrationfiltered
6. concentrationconcentrated in vacuo