Hydrazine hydrate (1:1) → 1H-pyrrole-2-carbohydrazonamide

HRID 2048131Notes

Reaction equation

HRID 2048131 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[N:7].C[O-].[Na+].O.[NH2:12][NH2:13]>C(O)C.O>[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:12][NH2:13])[NH2:7]

Participants

6

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 138277Pyrrole-2-carbonitrileHCID 10942334Sodium Methoxide

Product 1

HCID 1363872481H-pyrrole-2-carbohydrazonamide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of 1H-pyrrole-2-carbonitrile 10 g (108 mM) and sodium methoxide (1 eq) in ethanol (20 ml) and stirred for 10 min. Hydrazine hydrate (3 eq.) is then added and resulting reaction mixture is stirred at room temperature for 18 hrs. Reaction mass is then diluted with water, extracted with ethyl acetate, dried over anhydrous sodium sulphate and concentrated under vacuum to yield desired compound.

Workup

  1. customresulting
  2. customreaction mixture
  3. customReaction mass
  4. extractionextracted with ethyl acetate
  5. dry with materialdried over anhydrous sodium sulphate
  6. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-b2f4fdbed86e461184fdb9e306592e34
Source dataset
uspto-grants-2013_11
Patent number
US08592591B2

Reaction notes

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