2-Aminothiazole → 4-Imidazo[2,1-b]thiazol-6-ylbenzaldehyde

HRID 2048150Notes

Reaction equation

HRID 2048150 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1)=O.[NH2:13][C:14]1[S:15][CH:16]=[CH:17][N:18]=1>CN(C=O)C>[S:15]1[CH:16]=[CH:17][N:18]2[CH:2]=[C:3]([C:5]3[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=3)[N:13]=[C:14]12

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 17755522HCID 17755522, compound

Product 1

HCID 3982844-Imidazo[2,1-b]thiazol-6-ylbenzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.7 g (2.1 mM) 4-(2-Bromo-acetyl)-benzaldehyde and 2-aminothiazole (2 eq) are stirred in 15 ml DMF at 90° C. for 6 h. The DMF is evaporated and the residue suspended in ethyl acetate over night. The desired product is collected by filtration.

Workup

  1. customThe DMF is evaporated
  2. waitthe residue suspended in ethyl acetate over night
  3. filtrationThe desired product is collected by filtration

Sources & evidence

ORD record
ord-2a5795614f8649edbd6e590207faee45
Source dataset
uspto-grants-2013_11
Patent number
US08592591B2

Reaction notes

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