2-Acetylthiophene → HCID 20345883, compound

HRID 2049127Notes

Reaction equation

HRID 2049127 reaction equation
[C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2].[CH2:9]([NH2:13])[CH2:10][CH2:11][CH3:12]>C1(C)C=CC=CC=1.C(O)=O>[CH2:9]([NH2:13])[CH2:10][CH2:11][CH3:12].[C:1]([C:4]1[S:5][CH:6]=[CH:7][CH:8]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 69202-AcetylthiopheneHCID 8007Butylamine

Product 1

HCID 20345883HCID 20345883, compoundYield 90.4%

Reagents, catalysts & solvents 2

HCID 284Formic AcidCatalystHCID 1140TolueneSolvent

Procedure

756 g (6 moles) of acetyl-thiophene and 613 g (8.4 moles) of n-butylamine are azeotropically dehydrated in 2598 g of toluene in the presence of 15 g of formic acid. It is then concentrated under vacuum and mixtures of toluene and amine are thus recovered; 1081.6 g of acetylthiophene N-n-butylamine at 90% purity are obtained, namely a yield of 89.6%.

Workup

  1. concentrationIt is then concentrated under vacuum and mixtures of toluene and amine
  2. customare thus recovered

Sources & evidence

ORD record
ord-387fba6741cb4c4989b92f249de094a2
Source dataset
uspto-grants-1980_04
Patent number
US04196299

Reaction notes

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