Formaldehyde → HCID 12782916, compound

Anhydrous tetrahydofuran (THF) (825 ml) and 49.5 g (0.49 mole) of diisopropylamine were added to a dry three neck flask purged with nitrogen and maintained under a nitrogen atmosphere. After cooling the mixture to -20°, 300 ml of n-butyllithium in hexane (1.6 M) (0.49 mole) was added slowly to prevent the temperature from exceeding 0° and then 79.3 ml of anhydrous hexamethylphosphoramide (HMPA) (0.44 mole) was added. A solution of 51.28 g of palmitic acid (0.198 mole) in 400 ml of THF was added dropwise with stirring while maintaining the reaction temperature below 0°. A milky white suspension resulted after the addition of palmitic acid. The reaction mixture was brought to about 40° by using a warm water bath. The suspension changed to a clear solution as the temperature gradually reached 40°. This system was then connected to a formaldehyde generating system. Paraformaldehyde (40 g) was heated in a three neck flask at 180°-200° to generate formaldehyde and the formaldehyde vapors were carried by a stream of nitrogen over the surface of the stirred solution of α-lithiated lithium palmitate prepared previously. The reaction was terminated after complete depolymerization of paraformaldehyde (2 to 21/2 hrs.). The reaction solution was cooled in an ice bath and neutralized with hydrochloric acid until acidic. The organic layer was separated and was concentrated under reduced pressure on a rotavac to remove most of the THF solvent. The resulting oily residue was dissolved in 2 liters of ether and was washed three times with 10% hydrochloric acid solution and then twice with water. The ether layer was dried over Na2SO4 and the solvents were removed under reduced pressure to give 43.3 g (75%) of crude product, α-hydroxymethylpalmitic acid, which was recrystallized once from acetone to give 39.0 g (69% yield) of the product with m.p. 67°-71°, which was used without further purification in the next synthetic step.

1. customa dry three neck flask
2. custompurged with nitrogen
3. temperaturemaintained under a nitrogen atmosphere
4. temperatureAfter cooling the mixture to -20°
5. customfrom exceeding 0°
6. temperaturewhile maintaining the reaction temperature below 0°
7. customA milky white suspension resulted
8. customwas brought to about 40°
9. customchanged to a clear solution as the temperature gradually reached 40°
10. customprepared previously
11. customThe reaction was terminated after complete depolymerization of paraformaldehyde (2 to 21/2 hrs.)
12. temperatureThe reaction solution was cooled in an ice bath
13. customThe organic layer was separated
14. concentrationwas concentrated under reduced pressure on a rotavac
15. customto remove most of the THF solvent
16. dissolutionThe resulting oily residue was dissolved in 2 liters of ether
17. washwas washed three times with 10% hydrochloric acid solution
18. dry with materialThe ether layer was dried over Na2SO4
19. customthe solvents were removed under reduced pressure
20. customto give 43.3 g (75%) of crude product, α-hydroxymethylpalmitic acid, which
21. customwas recrystallized once from acetone

ORD record

ord-5e3ead8311a846fe80d8a6b8d19b3c63

Source dataset

uspto-grants-1980_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04196300