Hydrochloric Acid → 3-(5-Chlorothiophen-2-yl)-3-oxopropanenitrile

HRID 2049310Notes

Reaction equation

HRID 2049310 reaction equation
N[C:2]([C:6]1[S:7][C:8]([Cl:11])=[CH:9][CH:10]=1)=[CH:3][C:4]#[N:5].Cl.C[OH:14]>>[Cl:11][C:8]1[S:7][C:6]([C:2](=[O:14])[CH2:3][C:4]#[N:5])=[CH:10][CH:9]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 70567245HCID 70567245, compound

Product 1

HCID 125401813-(5-Chlorothiophen-2-yl)-3-oxopropanenitrile

Procedure

A 9.2 g. portion of β-amino-5-chloro-2-thiopheneacrylonitrile is dissolved in 100 ml. of methanol. A 50 ml. portion of 1 N hydrochloric acid is added and the mixture is stirred at room temperature for 3 hours. The precipitate is collected giving 5-chloro-β-oxo-2-thiophenepropionitrile.

Workup

  1. customThe precipitate is collected

Sources & evidence

ORD record
ord-65d65e208a7f457abb20222f095b3e8f
Source dataset
uspto-grants-1980_04
Patent number
US04197310

Reaction notes

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