反应详情

A solution of 3-(3-hydroxyphenyl)hexahydro-2H-azepin-2-one (2.05 g) in dry DMF was added dropwise to a suspension of sodium hydride (0.3 g). After 30 minutes at ambient temperature, benzyl chloride (1.3 g) was added. The mixture was stirred for a further 2 hours and then cooled, and treated with water. The resulting solution was extracted several times with toluene, and the combined toluene layers washed thoroughly with water. The solvent was evaporated to give an oil that crystallised from ethyl acetate to give the title compound as a white solid (1.4 g) m.p. 119°-122° C.

1. temperaturecooled
2. extractionThe resulting solution was extracted several times with toluene
3. washthe combined toluene layers washed thoroughly with water
4. customThe solvent was evaporated
5. customto give an oil that
6. customcrystallised from ethyl acetate