Water → HCID 12796479, compound

HRID 2049488Notes

Reaction equation

HRID 2049488 reaction equation
[CH2:1]([O:3][C@H:4]1[CH2:22][C@@:21]2([CH3:23])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:20]2[C:19](=[N:24]O)[CH2:18][C@@:17]2([CH3:26])[C@H:11]3[CH2:12][CH2:13]/[C:14]/2=[CH:15]/[CH3:16])[CH2:6][C@@H:5]1[OH:27])[CH3:2].O>C(O)CC>[NH2:24][C@@H:19]1[CH2:18][C@@:17]2([CH3:26])[C@@H:11]([CH2:12][CH2:13]/[C:14]/2=[CH:15]/[CH3:16])[C@H:10]2[C@H:20]1[C@:21]1([CH3:23])[C@@H:7]([CH2:8][CH2:9]2)[CH2:6][C@H:5]([OH:27])[C@@H:4]([O:3][CH2:1][CH3:2])[CH2:22]1

Participants

4

Reactant 2

HCID 962WaterHCID 86736929HCID 86736929, compound

Product 1

HCID 12796479HCID 12796479, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

A refluxing solution (under nitrogen) of (Z)-2β-ethoxy-3α-hydroxy-5α-pregn-17(20)-en-11-one 11-oxime (450 mg) in propan-1-ol (15 ml) was treated with pieces of Na (450 mg). When there was no trace of Na left the mixture was added to chilled water to give a fine precipitate which was collected by filtration.

Workup

  1. waitleft the mixture
  2. additionwas added
  3. customto give a fine precipitate which
  4. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-c5916c7df67241d0a978b165b9c129b0
Source dataset
uspto-grants-1980_04
Patent number
US04197296

Reaction notes

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