反应详情

7-Aminocephalosporanic acid (5.44 g., 20 mmole) and 5-Mercapto-1H-tetrazol-1-ylacetamide (3.50 g., 2.2 mmole) were suspended in 50% aqueous acetone (200 ml) and solid sodium bicarbonate added until a clear solution was obtained, ~pH 7.0. The solution was heated at 60° for 6 hours, uncovered for the final hour which allowed most of the acetone to evaporate, then acidified to pH 4.0 and stirred in an ice bath for one hour. The solid product was collected, washed with a little cold water and dried in vacuo, 3.22 g (43.4%), δ(CF3CO2H) 4.00 (2H,bs, C2 methylene), 4.69 (2H,bs, --CH2S--), 5.56 (4H,s, --CH2CO2NH2 and β-lactam protons), 7.4-7.8 (2H,m, --CONH2).

1. customwas obtained
2. temperatureThe solution was heated at 60° for 6 hours
3. customto evaporate
4. customThe solid product was collected
5. washwashed with a little cold water
6. dry with materialdried in vacuo, 3.22 g (43.4%), δ(CF3CO2H) 4.00 (2H,bs, C2 methylene), 4.69 (2H,bs, --CH2S--), 5.56 (4H,s, --CH2CO2NH2 and β-lactam protons), 7.4-7.8 (2H,m, --CONH2)