3,4-dihydro-2H-pyran → HCID 20344149, compound

HRID 2049659Notes

Reaction equation

HRID 2049659 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C@H:10]([OH:18])[CH2:11][C@H:12]2[CH2:16][CH2:15][CH2:14][N:13]2[CH3:17])[CH:7]=[CH:8][CH:9]=1.[O:19]1[CH:24]=[CH:23][CH2:22][CH2:21][CH2:20]1>Cl>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:10]([O:18][CH:20]2[CH2:21][CH2:22][CH2:23][CH2:24][O:19]2)[CH2:11][CH:12]2[CH2:16][CH2:15][CH2:14][N:13]2[CH3:17])[CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 80803,4-dihydro-2H-pyranHCID 70591371HCID 70591371, compound

Product 1

HCID 20344149HCID 20344149, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidCatalyst

Procedure

0.3 g of (R*,R*)-1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)-ethanol-hydrochloride, one drop of etheral hydrochloric acid and 3.5 ml of 3.4-dihydro-2H-pyran are stirred for 24 hours at room temperature and subsequently concentrated to 0.39 g of the oily hydrochloride of the title compound.

Workup

  1. concentrationsubsequently concentrated to 0.39 g of the oily hydrochloride of the title compound

Sources & evidence

ORD record
ord-a5c155ba562b4c959e0135f2b82978bb
Source dataset
uspto-grants-1980_04
Patent number
US04198424

Reaction notes

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