反应详情

In 50 ml of toluene, 4.44 g of n-butyrophenone, 6.40 g of pyrrolidine and 0.43 g of boron trifluoride etherate were dissolved. The mixture was refluxed for 47 hours using a Cope water separator and molecular sieve 4A as the dehydrating agent. After having distilled out the solvent under a reduced pressure, the residue was subjected to a distillation under a reduced pressure to obtain the desired enamine as a pale yellowish oil (yield: 4.66 g, 77%).

1. temperatureThe mixture was refluxed for 47 hours
2. distillationAfter having distilled out the solvent under a reduced pressure
3. distillationthe residue was subjected to a distillation under a reduced pressure