1-Phenyl-1-propanone → HCID 54049612, compound

HRID 2049760Notes

Reaction equation

HRID 2049760 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=O)[CH2:2][CH3:3].[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1.B(F)(F)F.CCOCC>[C:5]1([C:1]([N:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:2][CH3:3])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 2

HCID 71481-Phenyl-1-propanoneHCID 8082Piperidine

Product 1

HCID 54049612HCID 54049612, compoundYield 62.2%

Reagents, catalysts & solvents 2

HCID 8000Boron trifluoride etherateCatalystHCID 1140TolueneSolvent

Procedure

In 30 ml of toluene, 2.68 g of propiophenone, 5.30 g of piperidine and 0.14 g of boron trifluoride etherate were dissolved. The mixture was treated in a manner similar to Example 1 to obtain 2.50 g of the desired enamine (yield: 50%).

Workup

  1. additionThe mixture was treated in a manner similar to Example 1

Sources & evidence

ORD record
ord-18fc26d5417b4e33aba86803adf4dd8c
Source dataset
uspto-grants-1980_04
Patent number
US04198510

Reaction notes

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