反应详情

A mixture of Na2SO3 (2.7 g., 21 m.moles) and (3-(2-chloroethyl)pyridine (1.2 g., 8.5 m.moles) in water (10 ml.) was heated under reflux overnight with stirring and column chromatographed on IR-120 resin (H+, 100 ml.) by eluting with water. The eluate containing the desired product was collected and concentrated to give colorless plates (1.1 g., 69%), melting at 275°-278° C.

1. temperatureunder reflux overnight
2. customcolumn chromatographed on IR-120 resin (H+, 100 ml.)
3. washby eluting with water
4. additionThe eluate containing the desired product
5. customwas collected
6. concentrationconcentrated
7. customto give colorless plates (1.1 g., 69%), melting at 275°-278° C.