Cyclohexane → HCID 22810729, compound

HRID 2050044Notes

Reaction equation

HRID 2050044 reaction equation
[C:1]([N:8]([CH3:20])[C@H:9]([C:17]([OH:19])=O)[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:21][NH:22][CH2:23][CH2:24][CH2:25][S:26][CH3:27].C(OC(=O)C)C.C1CCCCC1>C(OC(=O)C)C.C1CCCCC1>[CH3:21][N:22]([CH2:23][CH2:24][CH2:25][S:26][CH3:27])[C:17](=[O:19])[C@H:9]([CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[N:8]([C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2])[CH3:20]

Participants

6

Reactant 4

HCID 8078CyclohexaneHCID 8857Ethyl AcetateHCID 7010602Boc-N-Me-Phe-OHHCID 18178029HCID 18178029, compound

Product 1

HCID 22810729HCID 22810729, compound

Reagents, catalysts & solvents 1

HCID 21867204Cyclohexane ethylacetateSolvent

Procedure

This was prepared by coupling BOCMePheOH with N-methyl-3-methylthiopropylamine by the method of Example 1(b). The pure product was obtained after silica gel column chromatography in ethylacetate/cyclohexane (1:3). Rf=0.52 (ethylacetate:cyclohexane, 1:1)

Workup

  1. customThis was prepared

Sources & evidence

ORD record
ord-45af636307194515bb518f8440368329
Source dataset
uspto-grants-1980_04
Patent number
US04199568

Reaction notes

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