Phenethylamine → 3-Methylthiopropan N-2-phenylethylamide

HRID 2050047Notes

Reaction equation

HRID 2050047 reaction equation
C[CH2:2][CH2:3][C:4](Cl)=[S:5].[C:7]1([CH2:13][CH2:14][NH2:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[CH3:7][S:5][CH2:4][CH2:3][CH3:2].[C:7]1([CH2:13][CH2:14][NH-:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 1001PhenethylamineHCID 22343826Butanecarbothioyl chloride

Product 1

HCID 867369493-Methylthiopropan N-2-phenylethylamide

Procedure

Prepared from 3-methylthiopropionyl chloride (2.76 g) and 2-phenylethylamine (5.04 g) by the method used in Example 10(a). The solid product (3.79 g) was pure by t.l.c. A sample crystallised from aqueous methanol as needles m.p. 56°-59°.

Workup

  1. customA sample crystallised from aqueous methanol as needles m.p. 56°-59°

Sources & evidence

ORD record
ord-2c699f3b86d548d88cacea4cb7971600
Source dataset
uspto-grants-1980_04
Patent number
US04199568

Reaction notes

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