Propargylamine → 1-Cyano-2-(2-propynylamino)-2-{2-[(thiazol-2-yl)methylthio]ethylamino}ethylene
Reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][S:7][CH2:8][CH2:9][NH2:10].[C:11]([CH:13]=[C:14](OCC)[NH:15][C:16]#[C:17][CH3:18])#[N:12].C(N)C#C.C(C=C(OCC)OCC)#N>>[C:11]([CH:13]=[C:14]([NH:15][CH2:16][C:17]#[CH:18])[NH:10][CH2:9][CH2:8][S:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][N:3]=1)#[N:12]Participants
5
Procedure
When 2-[(thiazol-2-yl)methylthio]ethylamine is reacted in an inert solvent with about an equimolar amount of 1-cyano-2-ethoxy-2-propynylaminoethylene [prepared from propargylamine and 1-cyano-2,2-bis(ethoxy)ethylene, which is itself prepared according to the procedure described in J. Am. Chem. Soc., 71, 47 (1949)], the title product is produced.
Workup
- customprepared
Sources & evidence
- ORD record
- ord-fe468824072d4cdbac32aa0d22865c62
- Source dataset
- uspto-grants-1980_04
- Patent number
- US04200578
Reaction notes
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