Propargylamine → 1-Cyano-2-(2-propynylamino)-2-{2-[(thiazol-2-yl)methylthio]ethylamino}ethylene
Reaction equation
S1C=CN=C1CSCCN.[C:11]([CH:13]=[C:14](OC)OC)#[N:12].[C:19]([CH:21]=[C:22](OC)[NH:23][CH2:24][CH2:25][S:26][CH2:27][C:28]1[S:29][CH:30]=[CH:31][N:32]=1)#[N:20].C(N)C#C>>[C:19]([CH:21]=[C:22]([NH:12][CH2:11][C:13]#[CH:14])[NH:23][CH2:24][CH2:25][S:26][CH2:27][C:28]1[S:29][CH:30]=[CH:31][N:32]=1)#[N:20]Participants
5
Reactant 4
Product 1
Procedure
When 2-[(thiazol-2-yl)methylthio]ethylamine is reacted with 1-cyano-2,2-bis(methoxy)ethylene [prepared according to the procedure described in J. Chem. Soc., (Suppl. Issue No. 1), S106-111 (1949)] and the resultant 1-cyano-2-methoxy-2-{2-[(thiazol-2-yl)methylthio]ethylamino}ethylene is reacted with propargylamine in the procedure of Example 1, the title compound is produced.
Workup
- customprepared
Sources & evidence
- ORD record
- ord-d796e6a1fb684cb68a7870d9a81f13d6
- Source dataset
- uspto-grants-1980_04
- Patent number
- US04200578
Reaction notes
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