HCID 86736962, compound → HCID 23335809, compound

HRID 2050376Notes

Reaction equation

HRID 2050376 reaction equation
[C:1]([O:4][CH2:5][C:6]1[CH2:13][S:12][CH:11]2[N:8]([C:9](=[O:30])[CH:10]2[NH:14][C:15](=[O:29])[CH:16]([C:26]([OH:28])=[O:27])[N:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18]2)[C:7]=1[C:31]([O:33]C(C)(C)C)=[O:32])(=[O:3])[CH3:2]>FC(F)(F)C(O)=O>[C:1]([O:4][CH2:5][C:6]1[CH2:13][S:12][CH:11]2[N:8]([C:9](=[O:30])[CH:10]2[NH:14][C:15](=[O:29])[CH:16]([C:26]([OH:28])=[O:27])[N:17]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18]2)[C:7]=1[C:31]([OH:33])=[O:32])(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 86736962HCID 86736962, compound

Product 1

HCID 23335809HCID 23335809, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 3-[(acetyloxy)methyl]-7-[[2-carboxy-2-(1H-indol-1-yl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, tert-butyl ester (0.05 mole) in 10 ml of trifluoroacetic acid maintained at 0° C. is stirred for 10 minutes. The trifluoroacetic acid is removed under vacuum. The residue is treated with ethyl ether to give a solid material. Filtration gives the title compound.

Workup

  1. customThe trifluoroacetic acid is removed under vacuum
  2. additionThe residue is treated with ethyl ether
  3. customto give a solid material
  4. filtrationFiltration

Sources & evidence

ORD record
ord-e04a2abe4f104046b2e45fcf50884427
Source dataset
uspto-grants-1980_04
Patent number
US04200747

Reaction notes

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