Sodium Chloride → HCID 70579374, compound

HRID 2050382Notes

Reaction equation

HRID 2050382 reaction equation
[O:1]=[C:2]1[NH:5][C@@H:4]([C:6](OC)=[O:7])[C@H:3]1[NH:10][C:11](=[O:20])[CH2:12][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[BH4-].[Na+].[H][H].C(=O)(O)[O-].[Na+].[Cl-].[Na+]>O1CCCC1.O.C(O)(=O)C>[OH:7][CH2:6][C@H:4]1[C@@H:3]([NH:10][C:11](=[O:20])[CH2:12][O:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:2](=[O:1])[NH:5]1

Participants

9

Reactant 5

HCID 5234Sodium ChlorideHCID 516892Sodium BicarbonateHCID 4311764Sodium borohydrideHCID 53649703Methyl cis-3-phenoxyacetamido-4-oxoazetidine-2-carboxylateHCID 178418361HCID 178418361, compound

Product 1

HCID 70579374HCID 70579374, compound

Reagents, catalysts & solvents 3

HCID 176Acetic AcidSolventHCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 13.5 g (0.049 mole) of methyl cis-4-oxo-3-phenoxyacetylaminoazetidine-2-carboxylate in 975 ml of tetrahydrofuran and 100 ml of water at 0° (ice bath) was added a cold solution of 3.75 g (0.099 mole) of sodium borohydride in 250 ml of water over a period of 10 min. The solution was stirred at 0° for 40 min and then glacial acetic acid was added dropwise until hydrogen evolution ceased. Solid sodium bicarbonate and sodium chloride were added and this mixture was extracted five times with 250 ml portions of ethyl acetate. After drying the combined extracts (MgSO4), the solvent was removed in vacuo. The resulting residue was dissolved in ethyl acetate, clarified with Norite and allowed to crystallize to give the title compound; tlc: ethyl acetate, silica gel GF, Rf=0.10; mp 153°-154° (ethyl acetate).

Workup

  1. extractionthis mixture was extracted five times with 250 ml portions of ethyl acetate
  2. dry with materialAfter drying the combined extracts (MgSO4)
  3. customthe solvent was removed in vacuo
  4. dissolutionThe resulting residue was dissolved in ethyl acetate
  5. customto crystallize

Sources & evidence

ORD record
ord-2c25cef5009a4b1f9e422fbbc4effbca
Source dataset
uspto-grants-1980_04
Patent number
US04200572

Reaction notes

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