Ethanone, 1-(2,5-dichlorophenyl)- → 2',5'-Dichloro-3-dimethylaminoacrylophenone

HRID 2050502Notes

Reaction equation

HRID 2050502 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH:10]=[CH:14][N:15]([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 75587Ethanone, 1-(2,5-dichlorophenyl)-HCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 28062062',5'-Dichloro-3-dimethylaminoacrylophenone

Procedure

A mixture of 31.0 g of 2',5'-dichloroacetophenone and 25 ml of N,N-dimethylformamide dimethyl acetal is heated on a steam bath for 6 hours, then evaporated to dryness in vacuo. The residue is slurried with hexane, filtered, and gives 35.3 g of 2', 5'-dichloro-3-dimethylaminoacrylophenone as orange crystals, mp 83-85° C.

Workup

  1. temperatureis heated on a steam bath for 6 hours
  2. customevaporated to dryness in vacuo
  3. filtrationfiltered

Sources & evidence

ORD record
ord-6a74682f6a8b4686aad3c6ad5e00ee90
Source dataset
uspto-grants-1991_05
Patent number
US05013737

Reaction notes

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