2,6-Xylyl isocyanate → HCID 15172040, compound

HRID 2050895Notes

Reaction equation

HRID 2050895 reaction equation
[C:1]1([C:7]2([NH2:12])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:15]=1[N:21]=[C:22]=[O:23]>C(OC(=O)C)C>[CH3:20][C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([CH3:13])[C:15]=1[NH:21][C:22]([NH:12][C:7]1([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:11][CH2:10][CH2:9][CH2:8]1)=[O:23]

Participants

4

Reactant 2

HCID 987872,6-Xylyl isocyanateHCID 1676511-Phenylcyclopentylamine

Product 1

HCID 15172040HCID 15172040, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1-phenylcyclopentyl amine (1.0 gm, 0.006 mole) in 30 ml of ethylacetate, 2,6-dimethylphenyl isocyanate (0.91 g; 0.006 mole) is added and the reaction mixture is stirred at room temperature for 20 hours. Volatiles are removed under reduced pressure and the residue is crystallized from ethylacetate-hexane yielding 1.65 g of N-(2,6-dimethylphenyl-N'-(1-phenylcyclopentyl) urea having a melting point of 227°-229° C.

Workup

  1. customVolatiles are removed under reduced pressure
  2. customthe residue is crystallized from ethylacetate-hexane yielding 1.65 g of N-(2,6-dimethylphenyl-N'-(1-phenylcyclopentyl) urea having a melting point of 227°-229° C.

Sources & evidence

ORD record
ord-76609ed160324f4b83a0c757e21b2c31
Source dataset
uspto-grants-1991_05
Patent number
US05015644

Reaction notes

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