HCID 14422542, compound → Imidazo[1,5-a]pyridine-3-sulfonamide

HRID 2051131Notes

Reaction equation

HRID 2051131 reaction equation
C([NH:5][S:6]([C:9]1[N:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]2=[CH:11][N:10]=1)(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[CH:11]1[N:10]=[C:9]([S:6]([NH2:5])(=[O:8])=[O:7])[N:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=12

Participants

3

Reactant 1

HCID 14422542HCID 14422542, compound

Product 1

HCID 19832737Imidazo[1,5-a]pyridine-3-sulfonamideYield 77.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N-(t-Butyl)imidazo[1,5-a]pyridine-3-sulfonamide (1.0 g) is dissolved in 20 ml of trifluoroacetic acid and stirred for 14 days at room temperature. The mixture is concentrated under reduced pressure, and ether is added to the residue to precipitate crystals. The crystals are collected by filtration and dried to give 0.60 g of the title compound. mp. 179°-180° C.

Workup

  1. concentrationThe mixture is concentrated under reduced pressure, and ether
  2. additionis added to the residue
  3. customto precipitate crystals
  4. filtrationThe crystals are collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-93a5aa6cf675491eb5055d96c4015b00
Source dataset
uspto-grants-1991_05
Patent number
US05017212

Reaction notes

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