Potassium Carbonate → HCID 14552913, compound

HRID 2051174Notes

Reaction equation

HRID 2051174 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:17][C:16](=[O:18])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[C:19]([F:22])([F:21])[F:20])[N:9]=2)=[CH:4][CH:3]=1.Cl[CH2:24][C:25]([N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1)=[O:26].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:17]=[C:16]([O:18][CH2:24][C:25]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[O:26])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[C:19]([F:22])([F:20])[F:21])[N:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 74040Morpholine, 4-(chloroacetyl)-HCID 67946912HCID 67946912, compound

Product 1

HCID 14552913HCID 14552913, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

The procedure is as in Example 1, but starting with 2-(4-chlorophenyl)-5-trifluoromethyl-4-quinolone (2.9 g), 4-(2-chloroacetyl)morpholine (1.62 g) and anhydrous potassium carbonate (2.5 g) in 2-butanone (60 cc). After recrystallization in acetonitrile, 4-{[2-(4-chlorophenyl)-5-trifluoromethyl-4-quinolyl]oxyacetyl}morphline (3.2 g), m.p. 179° C., is isolated.

Workup

  1. customAfter recrystallization in acetonitrile

Sources & evidence

ORD record
ord-c3c1a2e5d1a94866a1c1e6b9c1b96dbe
Source dataset
uspto-grants-1991_05
Patent number
US05017576

Reaction notes

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