反应详情

53 Grams of 60% sodium hydride was gradually added to a solution prepared by dissolving 256.2 g of cyclohexyl 3,5-dimethyl-2-hydroxyphenyl ketone in 1 liter of dimethylformamide with stirring, generating the temperature of the reaction mixture was risen to 70° C. by generating the heat. After continuation of stirring for 30 minutes, the reaction mixture was cooled to room temperature and thereto was added dropwise 233 g of methyl iodide. The reaction mixture was further stirred at the same temperature for 2 hours and then added to 1 liter of ice water and stirred. The organic layer was extracted with 3 liters of ethyl acetate. The extract was washed with water and then with a saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 285.2 g of cyclohexyl 3,5-dimethyl-2-methoxyphenyl ketone.

1. customprepared
2. customwas risen to 70° C.
3. stirringAfter continuation of stirring for 30 minutes
4. stirringThe reaction mixture was further stirred at the same temperature for 2 hours
5. stirringstirred
6. extractionThe organic layer was extracted with 3 liters of ethyl acetate
7. washThe extract was washed with water
8. dry with materialwith a saturated aqueous sodium chloride solution and then dried with anhydrous magnesium sulfate
9. distillationThe solvent was distilled off under reduced pressure