HCID 14986026, compound → HCID 14986027, compound

HRID 2051484Notes

Reaction equation

HRID 2051484 reaction equation
[CH2:1]([NH:3][C:4]1[C:5]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[N:6][C:7]2[C:12]([C:13]=1[N+:14]([O-])=O)=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH3:2]>CO.O1CCCC1.[Pd]>[NH2:14][C:13]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[C:4]=1[NH:3][CH2:1][CH3:2]

Participants

5

Reactant 1

HCID 14986026HCID 14986026, compound

Product 1

HCID 14986027HCID 14986027, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

The 3-ethylamino-2-morpholino-4-nitroquinoline (0.7 g, 0.0023 mol) was dissolved in a mixed solvent of methanol and tetrahydrofuran (15 ml) and subjected to catalytic reduction in the presence of 10g palladium-on-carbon (0.3 g), thereby obtaining 4-amino-3-ethylamino-2-morpholinoquinoline in an amount of 0.5 g (yield, 79%).

Sources & evidence

ORD record
ord-cda280e0f89041f3aa7ac38dc4409e0a
Source dataset
uspto-grants-1991_05
Patent number
US05019574

Reaction notes

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