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0 °C

5-chloro-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole (645 mg, 0.0019 mol) was dissolved in 25 ml CH2Cl2 and mixed with NaHCO3 (323 mg, 0.0038 mol) dissolved in 10 ml H2O. The stirred mixture was cooled to 0° C. and treated with MCPBA (84%, 389 mg, 0.0019 mol) dissolved in 6 ml CH2Cl2. After reacting for 10 min the layers were separted and the aqueous layer extracted with 5 ml CH2Cl2. The organic layers wcre combined and extracted with 20 ml water containing NaOH (154 mg, 0.0038 mol). The latter aqueous layer was collected (residual CH2Cl2 distilled off on the rotavapor) and treated with two portions of HCOOCH3 (2×118 μl, 0.0038 mol).

1. extractionthe aqueous layer extracted with 5 ml CH2Cl2
2. extractionextracted with 20 ml water
3. customThe latter aqueous layer was collected (residual CH2Cl2
4. distillationdistilled off on the rotavapor) and