Cyclobutylamine → HCID 14988397, compound

HRID 2051494Notes

Reaction equation

HRID 2051494 reaction equation
[N:1]1[N:2]=[N:3][N:4]2[CH:9]=[C:8]([C@@H:10]3[CH2:12][O:11]3)[CH:7]=[CH:6][C:5]=12.[CH:13]1([NH2:17])[CH2:16][CH2:15][CH2:14]1>C(O)C>[CH:13]1([NH:17][CH2:12][C@@H:10]([C:8]2[CH:7]=[CH:6][C:5]3[N:4]([N:3]=[N:2][N:1]=3)[CH:9]=2)[OH:11])[CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 75645CyclobutylamineHCID 13090314(R)-2-(tetrazolo[1,5-a]pyrid 6-yl)oxirane

Product 1

HCID 14988397HCID 14988397, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.75 g (4.62 mmol) of (R)-2-(tetrazolo [1,5-a]pyrid 6-yl)oxirane and 1.838 ml (22.8 mmol) of cyclobutyl amine in 1.8 ml of absolute ethanol was heated at 100° C. in a sealed reaction tube for 2 hours. The reaction mixture was concentrated to dryness under reduced pressure, wt. 0.997 g. Tlc, mass spectrum and 1H NMR spectra are consistent with good purity and chemical structure.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness under reduced pressure, wt. 0.997 g

Sources & evidence

ORD record
ord-506c230911b04a4dade6531d526903a4
Source dataset
uspto-grants-1991_05
Patent number
US05019578

Reaction notes

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